Exercise physiology is a complex science and the biological effect of exercise on muscle metabolism is much greater than initially thought.
It has been discovered that contracting muscle can induce secretion of molecules called myokines. Contracting skeletal muscles communicate with other organs such as bone, liver, adipose tissue and brain to exert beneficial effects of exercise at the whole body level.
Myokines are small secreted proteins that are released that have a specific effect on the interactions and communications between cells.
They play a significant role in protection against all the diseases associated with physical inactivity. One example is exercise-induced myokine can exert an anti-inflammatory action as written in the 2020, Advances in Clinical Chemistry, “Importantly, exercise-induced myokine can exert an anti-inflammatory action that is able to counteract not only acute inflammation due to an infection, but also a condition of chronic low-grade inflammation raised as consequence of physical inactivity, aging or metabolic disorders…”
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